Kai Wang

E-mail: wangkai0112006@163.com
Page: http://kaiwang0112006.github.io/
Phone: +86 13426113372

Technical Skills

Languages: JavaScript, Python, HTML5, CSS3, R, shell

Frameworks/Libraries: jQuery, D3.js, Django, Pyramid, Mako, sklearn, pandas, matplotlib, seaborn, ggplot2, networkx, beautifulsoup.

Database: mysql, mongoDB, neo4j.

Other: Git/GitHub, Bitbucket, Jira, Markdown, Letex.

Project Experience

MBKbase.org

Dec. 2014 - Present

Built a website for genotype, phenotype and germplasm search and data display. (Based on Pyramid framework)
Designed complex search function as data exploring tools.
Optimized function and MongoDB query that can speed up a page load from 1min to 3-4s.
Designed many interactive data visualization pages to enhance user’s exploring of data.(D3.js, ajax)

pyWebblast

Jan. 2016

Built a easy-to-use local web interface for ncbi blast+.
Enabled submitting sequence by inputting string or uploading file.

Assembly of transcriptomes of rubber tree

Dec. 2012

Build a assembly pipeline with Trinity and Cap3

Classification of Aurora Kinase inhibitors

Apr. 2011

Provided feature selection tools and the accuracy of the final model is 93.8%

Classification of HCV BS5B Polymerase Inhibitors

Aug. 2011

Provided feature selection tools with three different methods. Final model is enable to have an accuracy of 88.24%.

Prediction of Biological Activity of Acetylcholinesterase inhibitors

May. 2009

Built MLR and SVM models to predict the bio-activity of Acetylcholinesterase inhibitors.

Classification of Acetylcholinesterase inhibitors and decoys

May. 2009

Collected a dataset containing 714 inhibitors and 3892 decoys.
Designed different pipeline for feature selection.
Built several SVM classification models and the accuracy is up to 96.5%.

Work Experience

Institute of Genetics and Developmental Biology Chinese Academy of Sciences

Assistant Engineer

Aug. 2012- Present

Performed genome and transcriptome assembly.
Developed database and website development & data visualization.

BioDuro Co., Ltd

Intern

Jun. 2011-Jul. 2011

Developed interface for molecular properties calculation, structure search and library enumeration based on Rgroup and reaction
Assisted the update of compound database maintained in MDL® ISIS/Base

Education

Udacity

Jul. 2016

Data Analyst Nanodegree

MongoDB, Inc

Feb. 2015

MongoDB for python Developers

Beijing University of Chemical Technology

Jul. 2012

Chemical Engineering and Technology, M.S

Beijing University of Chemical Technology

Jul. 2009

Bioengineering, B.S

Publication

Dejun Li, Rizhong Zeng, Yan Li, Manman Zhao, Jinquan Chao, Yu Li, Kai Wang, Lihuang Zhu, Wei-Min Tian, Chengzhi Liang, Gene expression analysis and SNP/InDel discovery to investigate yield heterosis of two rubber tree F1 hybrids, Scientific Reports, 2016. 6:24984.
Kai Wang, Xiaoying Hu, Zhi Wang, Aixia Yan*, Classification of Acetylcholinesterase Inhibitors and Decoys by a Support Vector Machine, Combinatorial Chemistry & High Throughput Screening, 2012. 15(6), 492-502.
Aixia Yan*, Kai Wang, Quantitative structure and bioactivity relationship study on human acetylcholinesterase inhibitors, Bioorganic & Medicinal Chemistry Letters, 2012, 22(9), 3336-3342.
Maolin Wang, Kai Wang, Aixia Yan*, Changyuan Yu*. Classification of HCV NS5B polymerase inhibitors using Support Vector Machine. Int.J.Mol.Sci, 2012, 13(4), 4033-4047.
Aixia Yan*, Xianglei Nie, Kai Wang, Maolin Wang, Classification of Aurora Kinase inhibitors by Self-Organizing Map (SOM) and Support Vector Machine (SVM), Eur. J. Med. Chem, 2012(61), 73-83.
Aixia Yan*, Yang Chong, Liyu Wang, Xiaoying Hu, Kai Wang, Prediction of Biological Activity of Aurora-A Kinase Inhibitors by Multilinear Regression Analysis and Support Vector Machine, Bioorganic & Medicinal Chemistry Letters, 2011,21(8), 2238-43.
Kai Wang, Aixia Yan*, Introduction of several public databases for chemical activity on the Internet, Computers and Applied Chemistry, 2010,21(12):1629-1632.